LATEST RESEARCH 2021

Biomedicine & Pharmacotherapy Volume 143, November 2021, 112221

Cinnamon and its possible impact on COVID-19: The viewpoint of traditional and conventional medicine

Maryam Yakhchali 1, Zahra Taghipour 2, Mehran Mirabzadeh Ardakani 2, Mahdi Alizadeh Vaghasloo 3,Mahdi Vazirian 4, Sima Sadrai 5 Based on TPM and pharmacological studies, Cinnamomum verum(Darchini)’s potential effective functions can contribute to SARS – CoV- 2 infection treatment and has been known to be effective in corona disease in Public beliefs. From the viewpoint of TPM theories,Cinnamon can be effective in SARS – CoV-2 improvement and treatment through its anti- obstructive,diuretic, tonic and antidote effects. In addition, there is pharmacological evidence on anti – viral,anti inflammatory,antioxidant,organ-o-protective and anti-depression effects of Cinnamon that are in line with the therapeutic functions mentioned in TPM.Overall, Cinnamon and its ingredients can be recommended for SARS – CoV2 management due to multi – targeting therapies. This review provides basic information for future studies on this drug’s effectiveness in preventing and treating COVID-19 and similar diseases.

Cinnamon: A Promising Natural Product Against COVID-19

Azadeh Zareie 1 2, Davood Soleimani 3, Gholamreza Askari 1 2 4, Tannaz Jamialahmadi 5 6, Paul C Guest 7, Mohammad Bagherniya 8 9 10, Amirhossein Sahebkar 11 12 13 14 Affiliations expand PMID: 34279839 DOI: 10.1007/978-3-030-71697-4_15

Abstract COVID – 19 is a pandemic and acute respiratory disease. Every day, all around the world, researchers are endeavoring to find effective or potential adjuvant therapies. Studies illustrate that essential oils from cinnamon and derivatives such as cinnamaldehyde and cinnamic acid possess numerous biological activities. In this paper, we have reviewed the possible mechanisms of cinnamon on the inflammatory cascade as a potential alternative therapy to decrease oxidative stress and inflammation in COVID-19 patients.

INDIA.COM Benefits of Cinnamon in COVID-19: How it Fights Lung Infections And Boosts Immunity

Home Remedies:Benefits of cinnamon and how it saves you against coronavirus and other lung infections.Published: September 4,2020 6:27 PM IST By India. com Lifestyle Staff Email Edited by Anjali Thakur Email Follow Benefits of Cinnamon in COVID-19: While the world is reeling from the novel coronavirus, almost everyone is shifting to healthy/natural options to protect themselves from the virus. This is indeed a time when all of us need to take extra measures to stay safe this season. With the virus spreading many folds, fighting the infection is the need of the hour.Also Read – Omicron Becomes Dominant COVID- 19 Variant In THIS Country And that can be achieved if one takes care of their health and take precautionary measures. During this season,it is also common to catch a regular cold and cough too. But did you know, adding few spices to your daily diet can help you fight the regular flu too? Also Read – Rapid Antigen Tests Less Sensitive For Detecting Omicron Variant Infections: US Food and Drug Administration Adding cinnamon to your diet has many benefits. Don’t believe us? Cinnamon is a highly delicious spice, which has many medicinal properties.It has been used as an ingredient throughout history,dating back as far as Ancient Egypt. It used to be rare and valuable and was regarded as a gift fit for kings. These days, cinnamon is cheap,available in every supermarket,and found as an ingredient in various foods and recipes. Also Read – Breaking News LIVE: PM Modi To Chair Council of Ministers Meet Today: Omicron, Assembly Polls On Agenda Here are a few benefits of the delicious spice which can help you fight flu, cancer, and many more life-threatening diseases.

Keep your lung infections at bay – According to reports, one of the important components of Cinnamon i.e. Cinnamaldehyde may help fight various kinds of infection. The spice has shown that it has effectively treated respiratory tract infections caused by fungi by Taboola
May protect against cancer – According to many scientific reports, the cinnamon extract may protect against cancer. But this study was made on animals. These findings were supported by test-tube experiments, which showed that cinnamon activates protective antioxidant responses in human colon cells, it is not yet confirmed whether the spice has any effect on humans.
Boosts Immune system – This aromatic spice is a rich source of antioxidants which helps in giving a boost to your immunity system.You can prepare cinnamon with tea or lukewarm water with a hint of lemon.
It helps in reduced risk of heart diseases – Cinnamon has medicinal properties which may help and improve some key risk factors for heart disease, including cholesterol and blood pressure.
Helps in lowering Blood Sugar levels – This aromatic spice has over the years reduced the fasting blood sugars levels, it has a potent anti-diabetic effect. Add this kitchen ingredient to your daily diet and boost your immunity.

Could cinnamon modulate the immune response in severe COVID-19?

By Dr. Liji Thomas, MD Mar 18 2021

Since the coronavirus disease 2019 (COVID-19) pandemic’s first emergence, limited progress has been made in developing effective and safe antivirals to prevent and treat infection by the pathogen responsible, the severe acute respiratory syndrome coronavirus 2 (SARS- CoV- 2). A new study recently appeared in the journal Frontiers in Plant Science that describes the potential for two common plant products to make a difference in the management of severe COVID-19.Study: Cinnamon and Hop Extracts as Potential Immunomodulators for Severe COVID-19 Cases. Image Credit: AmyLv / Shutterstock In severe and critical COVID-19 patients, a so-called cytokine storm has been identified, characterized by exaggera-ted inflammation and acute respiratory distress syndrome (ARDS), often with multisystem damage and organ failure. The inflammatory response is due to the production of high levels of reactive oxygen and nitrogen species (ROS / RNS) that establish the vicious cycle of further inflammation. The inflammatory damage that can be done to the lung alveoli, the endothelium, and the ingrowth of blood vessels has become clear.

This type of inflammation centered on the blood vessels is not confined to the damaged lungs in COVID-19, but also involves sustained inflammatory changes in the liver, brain,gut and heart,among other organs. Thus, the ability to prevent or restrict the cytokine storm and reduce the oxidative stress on these organs would be useful in preventing death and could even, perhaps, reduce the viral load by suppressing viral replication. One such option has been dexamethasone, which reduces mortality by 30% in patients on ventilators. The current study is a follow-up of a prior screen that involved 99 herbal extracts thought to be anti- inflammatory. It zooms in on the top two, namely, Hop (Humulus lupulus, cones) and Ceylon cinnamon (Cinnamomum verum alias C. zeylanicum, bark) extracts.

These were found to bring about steep declines in activation of a key regulator of pro – inflammatory cytokines, namely, transcription factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells)

This Cinnamon-Flavoured Chewing Gum Can Reduce The Spread Of Covid-19, Study Says

The gum is laced with a plant-grown protein that can potentially decrease the viral load of the SARS-CoV-2 virus in saliva, by neutralising it, and reduce the transmission of the novel coronavirus By: Radifah Kabir/Updated : 06 Dec 2021 01:57 PM (IST)

New Delhi: Scientists from the University of Pennsylvania have developed a chewing gum that can reduce SARS-CoV-2 transmission, by acting as a “trap” for the novel coronavirus. The gum is laced with a plant-grown protein that can potentially decrease the viral load of the SARS – CoV-2 infection in saliva, and reduce its transmission, according to the study published recently in the journal ‘Molecular Therapy’.

The study was carried out in collaboration with researchers from The Wistar Institute and Fraunhofer, USA.

In a statement issued by the University of Pennsylvania, Henry Daniell, lead author of the study, said that the SARS-CoV-2 replicates in the salivary glands, and when an infected person sneezes, coughs, or speaks, some of the virus may be expelled and can reach others. He added that the gum offers an opportunity to neutralise the virus in the saliva, giving people a simple way to possibly cut down on a source of disease transmission.

Though vaccines have played a major role in changing the course of the pandemic, they have not ruled out transmission of Covid-19. Even people who have been fully vaccinated can become infected with the SARS-CoV-2 virus, and can carry a viral load similar to the unvaccinated, according to recent research.

Researchers Studied ACE2 Protein To Develop The Chewing Gum

Daniell had been growing a particular protein with a therapeutic potential in his lab, even before the onset of the pandemic. The protein, called angiotensin – converting enzyme 2 (ACE2), was being studied to understand its potential to treat hypertension, and was grown in the lab using a patented plant-based production system.

Coincidentally, the ACE2 receptor on human cells serves as the binding site for the SARS-CoV-2 spike protein. Also, injections of ACE2 can reduce viral load in people with severe infections, according to some studies.

The scientists bombarded the plant material with the DNA of target proteins, so that the plant chloroplasts could take up the DNA, and begin growing the proteins, the peer-reviewed study said. The plant material could be used as a means of delivering the protein, and was freeze-dried and ground-up. Protein drug synthesis is usually an expensive production and purification process, but the plant-based system helped the scientists overcome a lot of obstacles, the study stated.

Another group of researchers from the University of Pennsylvania were developing a chewing gum infused with plant-grown proteins to disrupt dental plaque. Daniell and his colleagues combined their research on ACE2 with the chewing gum technology. They infused a gum with plant-grown ACE2 proteins, to test its potential to neutralise SARS-CoV-2 in the oral activity.

Ronald Collman, another researcher at the University of Pennsylvania, said Daniell approached him to know whether one can internally validate the level of SARS-CoV-2 virus in the saliva samples. Collman said that Daniell’s approach of making the proteins in plants and using them orally is inexpensive and hopefully scalable.

ACE2 Incorporated Into Cinnamon-flavoured Gum Tablets

The researchers tested the chewing gum by growing ACE2 in plants, and paired it with another compound that enables the protein to cross mucosal barriers and facilitates binding, the study said. The scientists incorporated the resulting plant-material into cinnamon-flavoured gum tablets.

They also incubated samples obtained from nasopharyngeal swabs from Covid-19 infected patients with the gum, and observed that the ACE2 present could neutralise SARS-CoV-2 viruses, the study stated. The gum largely prevented the viral particles from entering cells, either by blocking the ACE2 receptor on the cells, or by binding directly to the spike protein, the study said.

The team of researchers exposed samples from Covid-19 patients to the ACE2 gum, and found that levels of viral RNA fell so dramatically that it became almost undetectable, the authors noted in the study.

The scientists intend to conduct a clinical trial to evaluate whether the approach is safe and effective when tested in people infected with SARS-CoV-2, and are seeking permission for the same. The chewing gum could be given to patients whose infection status is unknown, or even for dental check-ups, if the clinical trial proves the gum to be safe and effective.

The gum could reduce the likelihood of passing the virus to caregivers, the authors noted in the study. Daniell said the gum could be used as an additional tool, along with physical barriers such as masks, to reduce the chance of SARS-CoV-2 transmission.

By Hassina Leelarathna

Results of a scientific Research Study just released in the US and publicized by news media worldwide present a game changing bonanza for Sri Lanka Cinnamon Industry needs.

In the first known US study analyze levels of the banned toxic chemical coumarin in cinnamon products, University of Mississippi Scientists have basically given Ceylon Cinnamon, aka True Cinnamon, a gold seal of approval, affirming that it contains negligible traces of the chemical as compared to the cheaper substitutes imported from China, Vietnam and Indonesia.

The study appearing in the April issue of the Journal of Agriculture and Food and Chemistry(JAFC) published by the American Chemical Society warns that a high doses of coumarin could cause kidney and liver damage and calls for the setting of daily intake levels.

MIRACLE CURE- Given the exploding popularity of Cinnamon, not simply as a food flavorant, but a s a “miracle cure” for lots of health issues ranging from obesity to heart disease and arthritis,the findings spell boom time for the island’s cinnamon exports.

Google Will Have More and in Details

Cinnamon and Hop Extracts as Potential Immunomodulators for Severe COVID-19 OPINION article Front. Plant Sci., 26 February 2021

Cinnamon and Hop Extracts as Potential Immunomodulators for Severe COVID-19 Cases Published online 2021 Feb 26.

Cinnamon: A Promising Natural Product Against COVID-19 DOI: 10.1007/978-3-030-71697-4_15

Honey cinnamon tea to boost immunity and fight cold and flu TIMESOFINDIA.COM | Last updated on -Apr 27, 2021,

Cinnamon compound could be useful supplement to dexamethasone in COVID-19 treatment .Jun 17 2021

Could cinnamon modulate the immune response in severe COVID-19? Mar 18 2021